AZ-5104

Product Name: AZ-5104
CAS No.: 1421373-98-9
Chemical Name: AZ-5104
Synonyms: AZ5104;AZ7550;AZD5104;AZ-5104;CS-1709;AZ-5104;AZ 5104;AZ5104; AZ-5104;Demethylated AZ9291;metabolite of AZD9291;Osimertinib Impurity A
CBNumber: CB12741564
Molecular Formula: C27H31N7O2
Formula Weight: 485.58
MOL File: 1421373-98-9.mol

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AZ-5104 Property

Melting point:: 158 - 160°C
Density: 1.267±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.68±0.70(Predicted)
form: Solid
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17994
Product name: AZ 5104
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 17994
Product name: AZ 5104
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 17994
Product name: AZ 5104
Purity: ≥98%
Packaging: 25mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 17994
Product name: AZ 5104
Purity: ≥98%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

TRC

Product number: A795170
Product name: AZ5104
Packaging: 1mg
Price: $55
Updated: 2021/12/16

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AZ-5104 Chemical Properties,Usage,Production

Uses

AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).

Biological Activity

az5104, is the demethylated metabolite of azd-9291,is a potent egfr inhibitor. ic50 <1 nm, 6 nm, 1 nm, 25 nm, for egfr (l858r/t790m), egfr (l858r), egfr (l861q), and egfr (wildtype), respectively.egfr (epidermal growth factor receptor) is a receptor tyrosine kinase on the cell surface. the receptor activation leads to dimerization and tyrosine autophosphorylation. it induces downstream cellular responses such as modification in gene expression, cell proliferation and cytoskeletal rearrangement etc.compare to azd9291, az5104 has somewhat more potency in mutant egfr cell lines ex19del (2 nmol/l in pc-9), t790m (2 nmol/l in h1975), and wild-type egfr (33 nmol/l in lovo) cell lines. in a phenotypic assay, az5104 showed a greater potency across cell lines in a phenotypic assay.3 hours after oral dosing in the mouse, the circulating active metabolites in plasma is 33% for az5104. in both c/l858r and c/l+t mice, 5 mg/kg/day dose of az5104, also show efficacy in shrinking tumors.

References

1. cross da, ashton se, ghiorghiu s et al. azd9291, an irreversible egfr tki, overcomes t790m-mediated resistance to egfr inhibitors in lung cancer. cancer discov. 2014 sep;4(9):1046-61.

AZ-5104 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ-5104 Suppliers

China 109 India 4 United Kingdom 1 United States 16 Global 130

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

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View Lastest Price from AZ-5104 manufacturers

Career Henan Chemical Co

Product: AZ-5104 1421373-98-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

1421373-98-9, AZ-5104Related Search:

1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl- Osimertinib Impurity 7 Osimertinib Impurity N 2-Propenamide, N-[2-[[2-(dimethyloxidoamino)ethyl]methyloxidoamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 1,2,4-Benzenetriamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]- 1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-5-methoxy-N1-methyl-N1-[2-(methylmethyl-d3-amino)ethyl]- Osimertinib Impurity M N-(2-(dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide AZ 7550 1,4-Benzenediamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro- 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-2-propenamide

AZ5104

AZ-5104

N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

AZ7550

AZ5104; AZ-5104

N-[2-(2-dimethylaminoethylmethylamino)-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide

AZD5104

AZ-5104;AZ 5104

CS-1709

N-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Osimertinib Impurity A

2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-

Demethylated AZ9291

metabolite of AZD9291

1421373-98-9

C27H31N7O2

Inhibitors